Culmination- A symmetric ending?

Hello, readers!

For those of you who have traveled with us on our symmetrical journey, we've covered just about all the major topics involving symmetry-- from group theory to fluorocarbons to the ethics behind it all.

 

We've also encountered several comments and feedback from a couple of experts- such as researcher Dr. Sool Cho, who discussed with us briefly on the matter of whether chemistry-- and specifically symmetry-- is created or discovered. (Thank you again, Dr. Cho! Hope to hear from you again.)

In addition, don't forget about the numerous scientific breakthroughs-- such as the discovery (or creation?) of quasicrystals-- in which symmetry was critical! Indeed, we saw how symmetry really is everywhere around us.

 

But hold on! We're ending this introductory project, but just the fact that we've touched upon a lot of the topics at hand does NOT mean that our blog will  be over! In fact, it's just the opposite. Stick around, as we continue on with our journey.

(In fact, comment! Tell us what you liked about our blogs, or let us know of any symmetric discoveries that we did not mention! After all, the blog is nothing without you all reading.)

Buckyballs: a spherical perfection?

If you've ever looked at a chemistry textbook, you probably saw a molecule similar to this:

This is actually called a buckyball molecule! Specifically, its name is buckminsterfullerene, and it's comprised of 60 carbon molecules-- and nothing else.

(Did you notice that this exhibits an icosahedral symmetry? Try finding its point group!)

You can see exactly why this molecule made it to our blog-- it's SO symmetric, it almost looks like a perfect sphere!

(C60 fullerene solution)

This is essentially how these molecules were formed:

You can just imagine the countless properties that such a molecule would have. First of all, it's the largest molecule shown to demonstrate wave-particle duality! The discovery of this molecule actually led to a new field of chemistry, which studies JUST fullerenes!

What really intrigued us with this molecule is its attraction to each other in its solid form-- using van der Waals forces! Isn't it surprising, seeing how the molecule is so symmetric? How can they possibly attract each other and stick with each other?

Well, although the molecules are locked against rotation, with a little bit of heating the molecules quickly form face-centered cubics!

Isn't it interesting how even molecules as large and symmetric as these can still attract each other? Very interesting, huh?

The Buck Stops Here

Neil Degrasse Tyson

You have a duty, a responsibility. Constant reader, you must stop being indifferent, stop walking dully along in your poor lives and be enlightened by this information. Likewise you must tell others. Astrophysicist Neil Degrasse Tyson also harbors the same conviction. There is information in science that just makes him "want to grab people in the street and ask 'Have you heard this?'"Take a look at the image on the right and say whoa, slow down. The purpose of our mission, if we choose accept it, and I guess you have to because whether due to a case of internet intoxication or genuine curiosity you are reading this blog, is to educate the public on the symmetry of molecules.

Three words: context is key. We will now zoom out and take a look at symmetry through the eyes of the Synthesis of Symmetry blog we have made, not through the window of one individual post. Occam's Razor states that humans look toward the simplest hypothesis (or the hypothesis that makes the fewest number of assumptions). The human mind craves simplicity. We have three laws of motion, four law of electromagnetism, and physicists today even look for the theory of everything that will encompass quantum mechanics and general relativity. Is this why symmetry is key? Is this why synthesis of symmetry is sought after? Above we have the NaNb3O6 molecule. It self assembles, equally spaced, into black crystals. Arndt Simon and Tony Cheetham and coworkers have synthesized this molecule. This is an example that the chemist Roald Hoffman uses in his essay "Molecular Beauty."

Immanuel Kant

Hitherto a hobby to indulge in, synthesizing molecules like this open doors for lucrative opportunities. Then we get into the mess of patents and the subsequent formation of a monopoly and the ethics of microeconomics. That we will not comment on, but we will on the hobby of synthesis. Professor Hoffman offers Immanuel Kant as evidence. This argument purports that it makes people feel good about themselves. This is ridiculed by the German Enlightenment philosopher. His view is that people should refrain from activities that make the individual performing them feel good. The austere nonconsequentialist would find the synthesis of symmetry immoral. If you take the views of objectivist philosopher Ayn Rand, who espouses the opposite idea, synthesis of symmetry is the morally right thing to do.
What about the age old problem of discovery vs. synthesis? It feels better to create than to discover. This is analogous to the distinction between thermodynamics and kinetics. Now, we are not longer interested in the molecule (the end product) but the process by which we derived the symmetry. To speed up the reaction, there are catalysts. Does the symmetrical properties of these catalyst affect reaction rates? New evidence suggests yes. This example of symmetrical catalysts speeds up asymmetrical reactions. Natural processes are discovered but these catalysts are synthesized. The only conclusion that can be drawn is that synthesis serves to reinforce what is already there.

Buckminsterfullerene (hard to make)

Symmetrical Enzyme

I told you context is key. I have zoomed out on the synthesis of symmetry and looked beyond the minutiae of Group Theory and numbers and what not. These are the important questions that have been answered here today. These important questions utilized the real of kinetics in symmetry to accrue an answer. Think differently about your chemistry courses and apply any subject to any line of thinking (i.e. kinetics and thermodynamics to molecular symmetry). I promise you, once you do this, you will find answers to your questions. I know I did.

Group Theory-- Culmination!

So in the past couple of posts we've been talking about, among other things, group theory ! Recall that we talked about all of the major point groups and what each group includes. Finally, we'll explore exactly why those are important.

Mainly, group theory immediately answers whether any molecule can or cannot be polar or chiral.

1) Polarity:

Polarity is a subject that we touched upon in a lot of previous posts, and also something that you should be familiar with.

If you look at the H2O molecule above, you will notice that the oxygen atom "hogs up" the electrons within the hydrogen bonds! Thus this molecule-- water-- is polar.

In general, polar molecules will have asymmetric charge distributions-- i.e. some atoms will be more positively or negatively charged than others. This is caused by an intermolecular force called "dipole-dipole" interaction, in which the more positively charged atom(s) tend to pull the electrons closer to themselves, causing a shift in charge and a slight imbalance.

So how does this relate to group theory? Well, if we remember our point group table from before, you'll remember that there are many point groups involving the symmetric property that interchanges the two end-atoms of a molecule-- such groups include Dnd, which include a symmetry plane:

With such even symmetry, it's no surprise that molecules in that group can't have any uneven distributions of charge!

Moreover, if we look at Cn groups, we can see that the dipole moment cannot happen perpendicular to the axis of symmetry-- it's just to symmetric! For example...

If you see that one, it's just too symmetrically formed to share any dipole moments along the axis.

However, that doesn't always mean that Cn can't have any molecules with dipole moments. Take a look below:

For the specific molecule NH3 above, we can see that although there is an axis of symmetry, the molecule is still polar! Geometrically, we can see that all the hydrogens are "pointing down," causing an imbalance of charge.


So in conclusion, the following statement can be made:

"The only groups compatible with a dipole moment are Cn, Cnv and Cs."

 What do we mean when we say "compatible"? We mean that these are the only groups that might have dipole-dipole forces. Particularly, for molecules in Cn or Cnv, we can see that if anything, the dipole has to lie along the axis of rotation.



Next up:

2) Chirality:

Molecules that are chiral basically has a non-superimposable  mirror image molecule.

What does this mean? Well, if you're scratching your head at the confusion, just look at your two hands for a second:

You can easily get from one hand to the other by reflecting it across that mirror plane...But no matter how many translation operations that you try, you won't be able to recreate the other hand.

Now imagine that with molecules...that's what we mean. 

This next picture might help clarify more:

 

 

(The molecule in hand (pun intended) are enantiomers (isomeric pairs of molecules that are chiral) of a generic amino acid.)

Now here's the kicker-- group theory tells us exactly which groups of molecules can't have chiral molecules!

If we think about the symmetry operations, having any mirror planes or centers of inversion would definitely cross out the chances of having chiral  molecules, right?

With an inversion symmetry, for example, we know that any "mirror" image molecule can be superimposed using inversion.

And that's not all: the improper rotation can also preclude any chiral molecules:

The picture pretty much sums up the point-- that if a molecule has improper rotation symmetry, then its chirality can also be ruled out.

Therefore, the previous statements can be summed up as the following:

Any molecule with a center of inversion or a mirror plane of any type cannot be chiral. Otherwise, as long as the molecule cannot be improperly rotated, the molecule has the chance of being chiral. 

That's it for the very immediate consequences, but don't be fooled! Group theory has implications in chemistry far beyond what we just covered in this post.

So who said that math and chemistry don't mix? Clearly no one who knows about group theory!

Symmetrical Disease

That Symmetrical Butterfly

In our blog, we have discussed the connections between symmetry and molecules. However, too many people will respond to a question about symmetry by, not by talking about quasicrystals, but rather mentioning items such as butterflies and trees. This blog post will talk about the real life implications of symmetry, but instead of talking about pretty butterflies, we will dive into the topic of disease. This post will contain relatively few pictures due to the graphic nature of disease, and also the fact that some diseases are not visible to the human eye.



One rare disease in particular is named symmetrical peripheral gangrene, or SPG. The "normal" version of gangrene can be quite graphic, of course not as graphic as watching Gang Green (a.k.a The New York Jets), as the effected body part loses blood supply and turns a greenish, and eventually black color  (for your own sake DO NOT look up pictures of this!). The symptoms involve loss of feeling, confusion, fever, low blood pressure, and an intense pain. A couple of methods of contracting gangrene involve frost bite, surgery, diabetes, or a serious injury. However, the interesting stuff comes with the incredibly rare disease named symmetrical peripheral gangrene. This disease has an incredibly high mortality rate of 40%, and half of the people who survive must have a limb amputation.

If the left side is affected by SPG, so
is the right side

Now the interesting part of this disease comes with the symmetry in its name. Essentially this gangrene affects the extremities on both sides of the body, not just one limb like normal gangrene. Therefore, symmetrical gangrene would be seen on both legs, both feet, or both arms. Being an incredibly rare condition, there has not been much research conducted on the disease, so it is left up to us to hypothesize why symmetry is associated with the disease.  Could it pertain to the bacteria that infect the host? Maybe these bacterium are symmetrical in nature or grow colonies that are symmetrical. However, this would still not explain how the disease is in both limbs considering the large gap in between them. Since humans are known to be symmetrical, should whatever causes the blood vessels to constrict on the left side automatically occur on the right side? This theory seems to make the most sense, but if this is true, there would be no explanation on why this disease is so rare. It should then occur every time one is diagnosed with gangrene. There are many mysteries about this symmetrical disease that are still unsolved, and once scientists have a better understanding of the symmetry, a cure will follow soon after.

Knee Osteoarthritis

A study had been conducted to determine whether osteoarthritis is a symmetrical disease. Osteoarthritis, or OA, is the most common joint disorder that appears due to aging and over use. Some causes of OA are firm cartilage, the breakdown of cartilage  or the development of bone around a joint. As pain and stiffness are some of the worst symptoms of OA, which are MUCH less severe than SPG, (as in you will not die if you have OA), the symmetry in this disease is interesting but you do not  need common sense to determine where the symmetry comes from. The study which was mentioned previously focused on bilateral knee OA and studied patients over a 12 year span to determine if the condition is symmetrical. Now, your probably saying in your head right now: "Well of course this guy is going to find that the disease is symmetrical. If it is caused by wear and tear on a joint, such as running, and you run with two legs, both legs should develop OA". However knee OA is actually considered an asymmetrical disease. This is because each joint is considered its own, single, entity. After the conclusion of the study, it was determined that 80% of people with knee OA have it in both knees. The disease may not occur simultaneously in both knees, but over time, if one develops knee OA, he/ she can expect to get it in the second knee.

These symmetrical diseases have brought up many interesting questions for doctors and researchers alike. Does a symmetrical bacteria give rise to a symmetrical disease? How can a disease be symmetrical in two separate locations that are quite a distance away. Does the symmetry of the human body play a roll in this? Is the human body even symmetrical? Maybe scientists have to look deeper into the symmetry of the disease and human to realize, along with everyone else, that symmetry is not just that simple butterfly after all.

Fluorocarbon

          Lets talk about another cool symmetric molecule.

Perfluorohexane, a stable fluoroalkane liquid

Perfluoroisobutene, a reactive and toxic fluoroalkene gas

       Those two symmetric molecules are both in the group of molecules known as fluorocarbons. Fluorocarbons are basically hydrocarbons, but with all the hydrogen molecules replaced by fluorine. They are colorless and have densities up to twice the amount of water, mostly due to its high molecular weight. When compared to liquids of a similar boiling point, you see that this molecule has low viscosity values. This is due in part to the fact that the only force being applied to this molecule is London Dispersion Force. It also has low surface tension values and a low heat of vaporization. But here is the interesting thing. Because of those low values, this molecule tends to make a very good solvent for gases. Why am I telling you this? Well, because that simple property allows people and animals to do the one thing that has seemed to be beyond our grasp for quite a while, despite being able to such amazing things like getting to the moon. It allows you to breathe in a liquid.

Granted, you will be losing your mind though

     Yep, the picture above is of a hamster losing its mind, while being submerged in a fluorocarbon fluid. And while it does seem to be distressed, it is completely safe(ignoring the side effects). In liquid breathing, the patient is exposed to a perfluorocarbon mixture that has a high oxygen content. Since the mixture is fairly heavy, it sinks to the bottom of the lungs where it opens up the alveoli which leads to the lungs absorbing oxygen. The uses of this material and method is huge. They allow doctors to help people with damaged lungs and sick infants breath. And it would finally allow people to go to extreme depths without the fear of compression sickness and the bends.
      By using these flurocarbons, one is able to breath a liquid; a once impossible thought. And while it does have some side effects, it is very amazing what this symmetric particle is able to achieve. Thanks for reading.

A Theory of Knowledge: A Theory of Symmetry

Why does symmetry appeal to us?

We have spoken a lot about symmetry here on this blog. This blog is concerned with the symmetry of molecules, the building blocks of matter, in particular. But we have never answered the question: why? Why do we care about symmetry? It should be an arbitrary arrangement of molecules like any other. is there something special about symmetry? If one wants to get literary about this, one could argue along the lines of the archetype literary theory. Bear with me for a moment because I am going to proceed to blow your mind by utilizing some components of the IB course, Theory of Knowledge.
What do we know and how do we know it? We know babies spend more time gawking at people with symmetrical faces. This symmetry is thus determined by perception and reasoning. Molecular symmetry is significant because it explains data in quantum chemistry, spectroscopy, and crystallography. Chemists view chemistry not as a pinnacle of knowledge but as the median for understanding. Symmetry is the tool, not the birdhouse we all strive to create.

Symmetrical beauty?

Is it really ethical to give preference to symmetrical molecules over asymmetrical ones? Is this whole blog sinful and prejudiced? People with symmetrical faces (gauged as more attractive) earn more money for their work according to statistics and that surely is not ethical. We talk about the beauty of these molecules. Cromoglicic acid, shown above, is recognized for its aesthetics by people not even of the science fields. Juxtaposed with the molecule on the left, everyone would rather look at the symmetrical one. Not only this, but the symmetrical one is used for medicinal purposes. Is this suggestive of some connections between altruism and goodwill with symmetry and aesthetics?
There is a clear limit to how symmetrical something can be (perfectly symmetrical) but there is no roof or scale for how asymmetrical something can be. It was mentioned before that things tend to shift to a state of greater symmetry. So is this indicative of symmetry's stance as the promised land? It is basic human nature to favor some things over other simply because of first impressions and this has been proven by analyzing our response to these molecules. I submit to you that human ignorance literally starts at the microscopic level.